News and Information

Retrospective review of thienopyridine therapy in migraineurs with patent foramen ovale

We retrospectively reviewed our clinical experience using off-label thienopyridine agents in patients with migraine headache…

Ticagrelor for Refractory Migraine/Patent Foramen Ovale (TRACTOR)

After finding that the thienopyridines clopidogrel and prasugrel reduced migraine headache (MHA) symptoms in some…

The Multiple Clinical Manifestations of Patent Foramen Ovale

A patent foramen ovale (PFO) is a congenital remnant of the fetal circulation that persists…

Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke. Three previous randomized trials of…

Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke

Case–control studies have shown an association between patent foramen ovale (PFO) and cryptogenic stroke, particularly…

Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke

Between 20 and 30% of ischemic strokes are cryptogenic. A strong association between cryptogenic strokes and…

Patent Foramen Ovale and Cryptogenic Stroke in Older Patients

The cause of stroke remains unidentified by routine diagnostic testing in about 40% of patients. One…

Patent Foramen Ovale Closure: What Are the Indications?

An estimated 700,000 people experience an ischemic stroke in the United States every year. In…

Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts

The incidence and size of the patent foramen ovale were studied in 965 autopsy specimens…

Five-Year Outcomes of PFO Closure or Anti-platelet Therapy for Cryptogenic Stroke

In the initial report of the Gore REDUCE trial of patent foramen ovale closure, with…